Serious side effects include red blood cell breakdown, liver problems, and allergic reactions. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of. Ask your health care provider about possible side effects from ribavirin. Ribavirin is used in combination with other antiviral medications such as interferon, sofosbuvir to treat chronic longlasting hepatitis c, a viral infection of the liver. Treatment medications and side effects harvoni is a fixeddose combination tablet containing ledipasvir 90mg and sofosbuvir 400mg. Read this medication guide carefully before you start taking copegus. Get emergency medical help if you have signs of an allergic reaction. Ask your health care provider if there are interactions between ribavirin and the other medicines you take. Interferon alfa2b is made from human proteins that help the body fight viral infections. The standard treatment for hepatitis c hcv is the combination of interferon ifn and ribavirin rbv taken for 48 weeks. Apr 25, 2016 ribavirin is a drug used to treat hepatitis c. Jan 28, 2020 hypersensitivity side effects have included reactions such as urticaria, angioedema, bronchoconstriction, and anaphylaxis in patients treated with alfa interferon and ribavirin the active ingredient contained in rebetol severe skin reactions including vesiculobullous eruptions, stevensjohnson syndrome, erythema multiforme, and exfoliative. This includes any possible side effects not listed in this leaflet.
See below for a comprehensive list of adverse effects. In rare cases, this can lead to fatal heart problems. Nausea, diarrhea, stomach upset, headache, dizziness, blurred vision, trouble sleeping, cough, low appetite, weight loss or gain, dry skin, or changes in tastehearing may occur. It is used with interferon alfa to treat hepatitis c. The present metaanalysis study assessed the psychiatric side effects of peg ifn and ribavirin in iranian patients with chronic hepatitis c infection. Longterm effects of interferonribavirin hep c discussion. I also am on a 8 week treatment and have some nasty side effects i am on day 9 the migraines do subside but i still get daily headaches which are controllable with tylenol i was nauseas to the pint of vomitti g for the first 6 days but havent in the last few days i find now i have good and bad days and times throughout the day i take my meds. For more information ask your healthcare provider or pharmacist. Interferon alfa2b and ribavirin are packaged together as a capsule.
When used longterm, ribavirin can cause serious side effects. Managing side effects of sofosbuvir and ribavirin hepatitis. Apr 06, 2020 ribavirin must be used together with an interferon alfa product such as pegasys, pegintron, sylatron, or intron a to treat chronic hepatitis c. Ribavirin capsule oral rebetol side effects, medical. Other side effects that may be caused by ribavirin include inflammation of the pancreas pancreatitis, lung problems, eye problems, dental disorders, allergic reactions, and delayed growth in children. Ribavirin side effects, dosage, interactions drugs. Guidelines for use of inhaled ribavirin infectious. Copegus ribavirin dose, indications, adverse effects. Before taking ribavirin, tell your doctor or pharmacist if you are allergic to it.
You will take harvoni once daily by mouth with or without food. Common side effects of virazole include chest soreness, rednessirritation of the eye or eyelid, pinkeye conjunctivitis, breathing problems, irregular. Rbv is always used with other drugs, so it is not known whether there are differences in how well it works by age, gender, or race ethnicity. Common side effects of copegus taken with pegasys include. These side effects were evaluated in patients treated with peg ifn and ribavirin in order to determine whether it is reasonable to reduce these effects by replacing those drugs.
Side effects of virazole ribavirin, warnings, uses rxlist. The interferon alpha and ribavirin tail, with 180mcg of interferon weekly and a ribavirin dose of about 1200mg daily based on body weight has caused some really bizarre long term side effects in a small minority of patients, many of whom insist they. Some people develop anemia low red blood cell count from rbv, usually within the first few weeks of treatment. In addition, ribavirin has a multiple dose halflife of 12 days, and it may persist in nonplasma compartments for as long as 6 months. Keep a list that includes all prescription and overthecounter medicines, vitamins, and herbal supplements, and show it to your healthcare provider. Get emergency medical attention if you have chest pain. Although this therapy is effective against hepatitis c virus, it has several side effects 101. Ribavirin capsule oral rebetol side effects, medical uses.
Notify your provider of any adverse efects during treatment. It comes as an oral tablet, oral capsule, oral liquid solution, and inhalant solution. For more information, ask your healthcare provider or pharmacist. Ribavirin for intravenous administration is supplied in vials containing mg and 800 mg of ribavirin dissolved in 10ml phosphate buffer solution. There is no information on ribavirin side effects according to raceethnicity. Ribavirin oral tablet drug information, side effects, faqs. Unfortunately, this combination has serious side effects and is not very effective. Methods the terms hepatitis c, hepatitis c virus hcv, treatment, side effects, interferon, peginterferon, ribavirin, anaemia, haemoglobin, neutropenia, thrombocytopenia, haematological, growth factor, erythropoietin and gcsf were searched on medline for the period 19912009. Ribavirin can cause birth defects andor fetal death. Medication guide copegus copeguhs ribavirin tablets.
Guidelines for use of inhaled ribavirin infectious diseases. Gastrointestinal side effects associated with oral ribavirin in combination with peginterferon alfa2a, peginterferon alfa2b, or interferon alfa2b have included nausea up to 47%, nausea and vomiting up to 29%, diarrhea up to 22%, vomiting up to 14%, abdominal pain up to %, dry mouth up to 12%. Review side effects, drug interactions, dosage, and pregnancy safety information prior to taking any medication. The csf ribavirin concentrations were comparable to those at which ribavirin completely inhibited sspe virus replication without toxicity in. To avoid pregnancy, use at least 2 forms of contraception that includes a barrier method such as condoms plus an iud or diaphragm during treatment and for at least 6 months after treatment has inished. Managing side effects of harvoni and ribavirin ledipasvirsofosbuvir harvoni cough ribavirin. It is not clear whether rbv passes into breast milk. You may also report side effects to genentech at 18888352555. If experienced, these tend to have a severe expression.
Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Although its usage has been associated with a number of adverse effects, most of them are. You will take epclusa once daily by mouth with or without food. Talk to your childs doctor about the risks of giving this medication to your child.
Sideeffects, further information side effects listed are reported when oral ribavirin is used in combination with peginterferon alfa or interferon alfa, consult product literature for details. If you get any side effects, talk to your doctor or pharmacist. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about. If you have questions about this medicine talk to your doctor, pharmacist, or health care provider. These side effects may go away during treatment as your body adjusts to the medicine. Ribavirin must be used together with an interferon alfa product such as pegasys, pegintron, sylatron, or intron a. The description of adverse reactions is based on events from clinical studies approximately 200 patients conducted prior to 1986, and the controlled trial of aerosolized virazole ribavirin conducted in 19891990. Call your doctor for medical advice about side effects. The dosage regimen was 30 mgkg iv as a loading dose, then 16 mgkg iv every 6 hours for 4 days, followed by 8 mgkg iv every 8 hours for 3 days. Talk with your health care provider about possible side effects and how they will be managed. Call your doctor if you have any unusual problems while taking this medication.
Its typically prescribed in combination with other medications for up to 24 weeks. The risk for anemia from rbv is higher for people over 65 and women. Chronic hepatitis c infection can cause serious liver problems such as scarring cirrhosis, or liver cancer. The regimen of interferon plus ribavirin is rarely used in the united states. Pdf management of rare side effects of peginterferon and. Find medication information including related drug classes, side effects, patient statistics and answers to frequently asked questions. Check in frequently to read what others have to say, post your comments, and hopefully learn more about how you can reach your own health goals. Ribavirin may also be used for purposes not listed in this medication guide. These may be signs of a serious side effect of copegus treatment. Some medicines can cause serious side effects if taken while you. In canada call your doctor for medical advice about side effects. Management of rare side effects of peginterferon and ribavirin therapy during hepatitis c treatment.
Ribavirin must be used together with an interferon alfa product such as pegasys, pegintron, sylatron, or intron a to treat chronic hepatitis c. Pdf use of ribavirin for hepatitis c treatment in the. Ribavirin represents a nucleotide analogue of guanosine and a broadspectrum direct antiviral agent. What is the most important information i should know about. If you take harvoni with ribavirin, you should also read the ribavirin medication guide for important pregnancyrelated information. There were no major side effects or mortality associated with ribavirin. Patients should talk to their doctor about what to expect with treatment with. The most common side effects of rebetol in children include. Hemolytic anemia is a very low level of red blood cells. Ribavirin for intravenous administration virazole is of limited availability, produced by icn valeant for compassionate use under an investigational new drug ind application 7. Ribavirin oral tablet is available in a generic form. Lassa fevercomplicationsdrug therapy, ribavirinadverse effects. In addition, ribavirin has a multiple dose halflife of 12 days, and it may persist in nonplasma compartments for as long as 6. An open label trial of 194 patients ribavirin n140.
Ribavirin, once a staple of hepatitis c treatment, has significant drawbacks, including treatmentlimiting side effects, the requirement for intensive laboratory monitoring, the need for frequent. If you are having a serious side effect such as chest pain, please seek immediate medical attention. You may report side effects to health canada at 18662342345. Pharmacokinetics and effects of ribavirin following. Ribavirin may affect the way other medicines or products work, and other medicines or products may affect how ribavirin works. Common side effects include feeling tired, headache, nausea, fever, muscle pains, and an irritable mood. Significant teratogenic and embryocidal effects have been demonstrated in all animal species exposed to ribavirin.
Iv dosage n12 received iv ribavirin at the end of the trial when the iv became available for patients unable to tolerate oral ribavirin. Ribavirin may slow growth and weight gain in children. Virazole for inhalation solution is an antiviral drug used to treat infants and young children who have a severe lung infection caused by the respiratory syncytial virus. In addition, ribavirin has a multipledose halflife of 12 days and may persist in nonplasma compartments for as long as 6 months. Treatment medications and side effects epclusa is a fixeddose combination tablet containing sofosbuvir 400mg and velpatasvir 100mg. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is. The large registration trials of directacting antiviral daa agents used for the treatment of chronic hcv infection have generally excluded patients with significant renal impairment, frequent side effects that were likely directly related to the ribavirin, including anemia, fatigue, nausea, and diarrhea, and 9 of patients interrupted. The side effects of ribavirin described in the boxed warning include. Significant teratogenic andor embryocidal effects have been demonstrated in all animal species exposed to ribavirin. Rebetol ribavirin side effects, images, uses, dosage. Ribavirin rebetol, copegus, ribasphere, ribapak, moderiba is a drug used in combination with interferon for the treatment of chronic hepatitis c. Nausea, diarrhea, stomach upset, headache, dizziness, blurred vision, trouble sleeping, cough, low appetite, weight loss or gain, dry skin, or.
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